Inside Cover: A Trimodal Closomer Drug-Delivery System Tailored with Tracing and Targeting Capabilities (Chem. Eur. J. 36/2016)

Synthesis of some network polymers with siloxane units as a drug delivery system

New biodegradable network polymers containing siloxane-linked polymeric prodrugs of 5-ammino-2-hydroxybenzoic acid (5-ASA) in the main chain were prepared by ter polymerization of methacrylic acid (MA), 2-hydroxyethylmethacrylate (HEMA), and bis (trimethylsilyloxy) methylsilane (VBM) in the presence of some new cross-linking agents.The monomers and polymers were characterized by FT-IR and 1H-NM...

Phytosome: Drug Delivery System for Polyphenolic Phytoconstituents

      Several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or destruction in gut. Drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phytoconstituents with phospholipid mainly phosphatidylcholine wh...

Targeting : New Potential Carriers for Targetted Drug Delivery System

At present 95 percent of all new potential therapeutics have poor pharmacokinetic and biopharmaceutical properties. Hence there is need to develop a suitable drug system that distributes the therapeutically active drug molecule only to site of action, without affecting healthy tissue or organ. Drug delivered can have significant effect on its efficacy. Some drugs have an optimum concentration r...

Tetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system

PURPOSE Nanoparticles (NPs) that target bone tissue were developed using poly(lactic-co-glycolic acid) (PLGA) copolymers and tetracycline (TC)-based bone-targeting moieties. These NPs are expected to enable the transport of drugs, such as simvastatin (SIM), for the treatment of osteoporosis. METHODS The molecular structures of TC-PLGA were validated by (1)H-NMR, and the SIM-loaded NPs were pr...

drug delivery and targeting in traditional iranian pharmacy